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www.chemasianj.org
1/07
2012
Focus Review
Chemical Synthesis of the Englerins
D. Y.-K. Chen et al.
A sister journal of Angewandte Chemie
and Chemistry – A European Journal
CAAJBI 7 (1) · 1–244 (2012) · ISSN 1861-4728 · Vol. 7 · No. 1
A common limitation of…
… gold nanoparticle (Au NP)-based sensing in natural samples is that non-specific
binding of biomolecules on the Au NP surface interferes in sensing systems and
causes a reduction in the selectivity and sensitivity. To circumvent such a limitation, a
recently developed hollow nanoreactor with a nanorattle structure, consisting of a
porous silica nanoshell and an entrapped Au NP, was employed. As described in
their Communication on page 36 ff., I. S. Lee et al. report that the catalytic Au
growth inside the protected cavity, which is accompanied by an SPR enhancement,
allows for the quantitative detection of H2O2 and glucose concentrations, even in the
presence of the interfering BSA proteins.
Total synthesis
Englerin A is a recently reported guaiane sesquiterpenoid characterized by its
densely functionalized 5-6-5 oxo-bridged tricyclic system with seven stereogenic
centers embedded. In conjunction with its potent and selective anti-cancer property,
englerin A received immediate attention from the synthetic community as an fertile
testing ground for modern synthetic technologies and strategies. In their Focus
Review on page 22 ff., D. Y.-K. Chen et al. discuss the contrasting approaches
developed for the synthesis of englerin A originating from the laboratories of the
pictured researchers, showcasing the state-of-the-art synthetic organic chemistry and
setting the stage for the development of novel chemotherapeutics.
Chemoenzymatic synthesis
In their Full Paper on page 64 ff., S. Aoki et al. demonstrate that all possible
stereoisomers of 1,3-diols can be produced with high diastereo- and
enantioselectivities by a one-pot chemoenzymatic synthesis in water. The synthesis
involves an enantioselective aldol reaction catalyzed by a chiral Zn2 + -complex
catalyst and successive enantioselective reduction of the aldol product using an
oxidoreductase, with regeneration of NADH.
Chemistry—An Asian Journal is co-owned by the thirteen chemical societies shown
and is published by Wiley-VCH. This group of societies together form the Asian
Chemical Editorial Society (ACES) for its combined publishing activities.
Chemistry—An Asian Journal is supported by the Chemistry Publishing Society
Europe (ChemPubSoc Europe) and the Gesellschaft Deutscher Chemiker (German
Chemical Society).
Chem. Asian J. 2012, 7, 3
2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
www.chemasianj.org
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