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April 11, 1950
Filed Jan. 28, 1949
A %w7,amm
Patented Apr. 11, 1950
I ‘ .
.iINHALATOR 1A. 1:.i-Heisterkamp, Wynncwwd, Pa, as
; Signor wto» Wyeth incorporated, Philadelphia,
. .-P-a., a corporation of Delaware
Application January 28, 1949, SerialNou7~3§24é2
v.2 Claims. (01. .12_8-20.7.)
This invention relates to inhalators and more
?llediintoi the; tube» 212 through» ‘its. vopen : rend 4.8.
particularlyto that typeof such'device primarily
Fig. ;.1,;.2il
;_and 1.24 are
the unit
then may
. applied-‘as.
be properly
lized and toreprisesv a package forpthemediea»
adapted for use in connectionrwith the inhalation,
both oral :or nasal_,,.of penicillin or streptomycin
.dust ‘or similar pulverulent materials.
‘With this and other objects in .view the inven
tion consists inthedetails of. an inexpensive but
‘Thei?tment :19 is zannularlyzzrecessed :as .ata'l?cto
receive .aimeshedscreen 23. covering- the central
bore iii. le-rbushi-ng’ldi .rubber or other :suit
able. clastumer ‘is seated; belowthe- screen" wand
efficient inhalator, convenient ‘for use and of low
costfto ithe user so that ‘?she :.device may .be dis
has a centra1».bore':_2:5 in . iine withethe-rbore ‘ to,
carded following the administration of :the con
such bore 2-5. beinaoflarger diameter at its outer
tained medicament.
Referring to the accompanying drawing wherein
end 26. A ?ange 21 engages the external pe
riphery of the wall of the recess 22.
like reference numerals indicate the same parts
Flange 21 may be eliminated, if desired, and the
Fig. 1 is a perspective view of the medicament 15 bushing 24 seated entirely within the recess 22.
When it is desired to use the device for inhala
tion, caps 20 and 2! are removed from the tube
l2 and the upper end l3 thereof inserted ?rmly
containing cartridge;
Fig. 2 is a like view showing the cartridge seal
ing caps removed;
Fig. 3 is a vertical cross-section of the device
completely assembled;
in bore 25 of the bushing 24. Since commercial
20 glass tubing similar to that used for tube 12
varies in diameter, the tapering of the bore 25
inwardly from the point 26 of largest diameter,
together with the inherent elasticity of bushing
24, permits an interacting wedging action between
Fig. 4 is a top plan view of Fig. 3;
Fig. 5 is a perspective view of the valved seal
ing plug for the cartridge base;
Fig. 6 is an expanded perspective view of the
nose or mouthpiece in disassembled relation‘;
Fig.7 is an enlarged sectional view of the valved
tube l2 and bushing 24 to hold tubes of varied
diameters within the accepted tolerance.
When thus assembled, as shown in Fig. 3, the
inhalator is ready for use. Insertion of the piece
9 into the mouth or nasal passage as is desired
followed by inhalation will create a suction in the
tube l2 through the aligned bores l0 and 25 caus
ing the dust I9 to move upwardly opening the
valve 18 to allow outside air to enter through
bore l'l whereupon the entire dose of pulverulent
sealing plug shown in Fig. 5; and
Fig. 8 is a top plan view of a modi?ed form of
the nose or mouthpiece.
The use of the device is built around the asso
ciation of a mouth or nosepiece, designated as a
whole by the numeral 9 and having a central bore
10 and secondary air intake passages ll, either
two or four in number (Figs. 4 and 8), with a
cartridge for containing the medicament. This
cartridge comprises a short piece of tubing [2
preferably of glass or transparent plastic, open
at its top end l3 and plugged at its lower end I4
by a valved stopper 15. Such plug stopper I5
. medicament will be inhaled by the user, screen
23 effectively overcoming particle coherence as
the dust passes therethrough. Secondary air in
troduced through passages H promotes turbu
lence and further aids in dispersal and distribu
is formed of rubber or other suitable elastomer 40 tion of the entrained dust.
Upon evacuation the empty tube l 2 is discarded
to insure snug ?tting within the tube l2 and is
and additional dosage secured as desired by the
provided with an outer ?ange 16 which limits
successive use of new ?lled cartridges inserted as
the inward movement of the plug stopper in the
tube by seating upon the end of the tube through
My device is adapted to be sold in a unit‘pack
out the circumference thereof. A central air in 45
age in any desired conventional container or
take I‘! is normally closed by a flap valve [8 which
wrapping, one nose piece being packed with one
can, upon the application of suction or pressure,
or more charged cartridges, capped or otherwise
assume an open position as indicated by the
sealed, ready for assembly with the nose piece on
dotted lines in Fig. '7.
removal of the caps or other closures. Additional
If desired, the ?ange [6 may be dispensed with
charged and capped cartridges may also be sold
and the plug l5 seated completely within and
below the end M of the tube l2.
I claim:
. In practice the cartridge is closed at its lower
1. An inhalator adapted for dispersal and dis
end by insertion of the plug l5 and a measured
amount of the medicament dust, shown at l9,
tribution of therapeutic dust in the respiratory‘
passages by inhalation which comprises a nose
piece and a medicament-containing cartridge,
portion of the axial bore in a position to retain
said screen, the inner bore of said bushing being
the nose piece having an axial bore one end of
which is of a size to receive one end of the said
alined with and forming a combination of the
axial bore of the nose piece and being of a size
cartridge with a snug ?t, the cartridge being of
to receive the proximal end of said cartridge with
generally cylindrical tubular form, open at the
end ?tting into the nose piece and closed at the
opposite end by a one-way valve arranged to ad
mit air through that end to the inhalator, the
nose piece further being provided with at least
one radial passage admitting secondary air to the
axial bore to promote turbulence of air inhaled
therethrough and being provided with a screen
a snug slip ?t, the cartridge being of a generally
cylindrical tubular form of a size to ?t snugly in
said bushing, the proximal end of said cartridge
being open and the distal end being closed by a
pierced valved plug, the valve in said plug being a
one-Way valve arranged to retain powdered ma
terial in the cartridge when not in use and dur
ing inhalation to admit air to the distal end of
across the axial bore effective to overcome par
the cartridge but prevent air from issuing there
ticle coherence of entrained dust passing there
from on accidental reversal of pressure.
2. An inhalator adapted for dispersal and dis
tribution of therapeutic dust in the respiratory
passages by inhalation which comprises a nose
piece and a disposable medicament-containing
cartridge, the nose piece having a generally ta
The following references are of record in the
?le of this patent:
pered cylindrical form, the proximal end being of
a size adapted for apposition to an exterior open
ing of the human respiratory tract, the nose piece
being formed of an elastic material and having
an axial bore to admit air to the respiratory tract
Bosworth _______ __ July 31, 1923
Fields _____ _'______ May 17, 1949
Fields __________ __ May 17, 1949
and at least one radial passage to admit sec
ondary air to the axial bore, a screen positioned
across the axial bore effective to overcome particle
coherence of entrained dust passing there
through, an elastic bushing seated in the distal
Great Britain _______ _- A. D. 1887
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