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Histology of the Male Reproductive System

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Histology of the Male
Reproductive System
(Repro 5)
PROF. DR. FAUZIAH OTHMAN
DEPT OF HUMAN ANATOMY
Contents
• Histology of testes
• Histology of vas deferens
• Histology of seminal vesicle
• Histology of prostate gland
• Histology of the Bulbourethral gland
Histology of testes
•Tunica albuginea• dense white fibrous capsule
• composed of dense irregular connective
tissue,
•forming septa that divide each testis into
series internal compartments called lobules.
Spermatogenesis in seminiferous tubules
Seminiferous tubules
• Stratified germinal epithelium
• Surrounded by a layer CT with fibroblast
and an inner basement membrane (bm).
– Consist: Supporting (Sertoli cell)
пЃ¶ Slender,
elongated cells with irregular outlines that
extend from the bm.
пЃ¶ Primary spermatocytes
пЃ¶ Spermatocytes
пЃ¶ Spermatids
Spermatogenesis
• Process where the spermatogenic cells in the
•
seminiferous tubules divide, differentiate, and
produce sperm.
3 phases
– Mitotic division of spermatogonia
– Meiotic division of spermatocytes,
somatic
chromosome no. – spermatids
– Spermiogenesis morphological transformation
spermatids
sperm.
Testes produce both testosterone
and sperm
• LH and FSH are produced by the pituitary gland.
• LH binds to receptors on the interstitial cells (Leydig
cells) and stimulate testosterone.
• FSH stimulates Sertoli cells to synthesize and release
ABP (androgen-binding protein) into seminiferous
tubules to stimulate spermatogenesis.
• ↑ concentration of testosterone essential for proper
spermatogenesis.
Sertoli cells
• Supportive cells in the seminiferous
tubules located among the spermatogenic
cells
• Fx: physical support, protection and nutrition of
the developing sperm (spermatids)
• Phagocytosis of cytoplasm developing sperm
(spermatids)
• Produce and release ABP.
Seminiferous tubule, straight tubules,
rete testis & ductuli efferentes
Ductuli efferentes of the ductus epididymis
Histology of vas deferens
Vas deferens
• A narrow and irregular lumen with longitudinal mucosal
folds.
• Psuedostratified columnar epithelium with stereocilia.
• Thin lamina propria
• consists of compact colagen fibers and fie net work of elastic
fibers.
• Thick muscularis
• 3 SM layers
– Inner longitudinal
– Middle circular
– Outer longitudinal
• Adventitia.
• Abundant of blood vessels
Ampulla of the vas deferens
• Terminal portion of the vas deferens enlarges
•
into an ampulla
Lumen of ampulla larger than vas deferens.
• Numerous irregular branching mucosal folds
• Deep glandular diverticula or crypts
• Simple columnar or cuboidal epithelium.
• Lamina propria
• 3 layers of SM
• Thin inner longitudinal
• Thick middle circular
• Thin outer longitudinal
Ampulla of the vas deferens
Accessory reproductive glands
• Seminal vesicles
• Yellowish viscous fluid high in fructose
• Energy source for sperm motility
• Produce most fluid found in semen
• Prostate gland
• Porduce thin, watery slightly acidic fluid
• The enzyme fibrinolysin liquefies the semen after ejaculation.
• Bulbourethral glands
• Produce clear, viscid, mucus-like secretion during erotic stimulation
• As lubricant for thr penile urethra.
Histology of seminal vesicle
Glandular epithelium of seminal vesicles normally
varies
low pseudostratified, low columnar or
cuboidal.
Prostate gland & prostate
urethra
• Prostate gland
• Prostetic urethra
– Psuedostratified epithelium
• Glandular acini vary in size
• Lumina of acini normally wide and irregular
– Protrusion of epithelium-covered connective tissue folds
– Proteinaceous secretions sometimes prostatic
concretions.
– Glandular epithelium simple-columnar or psuedot
Fibromuscular stroma
– Characteristic feature of prostate gland
пЃ¶ SM bundles and CT fibers blend together in the
stroma throughout the gland.
пЃ¶ ratified, cells lightly stain, some region squamous or
cuboidal.
Histology of prostate gland
Histology of the Bulbourethral
gland
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