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Peripheral neuropathy ed 3 vols I and II. Edited by Peter James Dyck MD P. K. Thomas CBE MD DSc. FRCP John W. Griffin MD Phillip A. Low MD and Joseph F. Poduslo PhD Philadelphia WB Saunders 1993 1 720 pp. illustrated. $335

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BOOKS
Reviews
The Treatment of Epilepsy: Principles and Practice
Edited by Elaine Wyllie
Philadelphia, Lea G Febiger, 1993
1,238 pp, illustrated, $99.50
As stated in the preface, this book is intended to be “a single
reference with a broad but very detailed overview” of the
field of epilepsy. D r Wyllie and her coauthors have succeeded in their goal. With 103 chapters, 128 authors, and
1,238 pages, the book is an encyclopedia covering topics
ranging from basic neuronal physiology to the psychosocial
effects of epilepsy on patients and their families. The author
list is a veritable “Who’s Who” in the field of epilepsy today.
Most chapters make for easy and enjoyable reading, and the
index is sufficiently detailed.
Like most other books of this size and scope, there are
occasional inconsistencies and redundancies in the text. For
example, there appear to be conflicting opinions about the
presence of morphological changes in kindling, or the potential importance of a mirror focus. In this regard, it might be
helpful to introduce each of the six main sections of the book
with an overview of some of the central issues that continue
to be controversial or poorly understood. Readers need to
be wary of potential mistakes as well. For example, the algorithm for the management of status epilepticus on page 873
suggests using phenobarbital at a loading dose of 0.05 mgi
kg followed by 0.1 mgikgimin. I presume the authors intended to suggest different doses for phenobarbital, or another regimen using pentobarbital.
Regardless, these minor shortcomings are easily offset by
the fact that this book conveys a tremendous scope of experience in an unusually accessible format. I highly recommend
The Treatment of Epilepsy to anyone who wants a singlereference text on epilepsy.
Daniel H . Lowenstein, MD
San Francisco, CA
Peripheral Neuropathy, ed 3, Vols I and I1
Edited by Peter James Dyck, MD, P. K. Thomas, CBE, M D ,
DSc. FRCP, John W. Grz$n, MD, Phillip A . Low, MD. and
Joseph F. Poduslo, PhD
Philadelphia, WB Saunders, 1993
1 I 720 pp. dlustrated. $335.00
This standard two-volume reference on diseases of peripheral
nerve is now in its third edition. In the 9 years since the
second edition, numerous advances have been made in our
understanding of the peripheral nervous system and the neuropathies. The thoroughly revised third edition incorporates
these advances quite well. To accomplish these changes, Drs
Dyck and Thomas have recruited the assistance of Drs Griffin, Low, and Poduslo.
In the initial 28 of 38 chapters in the first volume, the
structure, function, development, and other aspects of the
neurobiology of the peripheral nervous system (PNS) are
reviewed in depth. Ten of these chapters are new with this
edition and address topics such as channel function, impulse
propagation, axon-Schwann cell interactions, neural growth
factors, and immune reactions in the PNS. These represent
important additions to the third edition that provide a more
inclusive and contemporary review of the neurobiology of
the PNS than is contained in the earlier editions. Twelve
other chapters have a change in authorship and a considerable
change in content. Thus, with over three-fourths of the initial
sections of the third edition so different from the second,
the basic chapters covering neurobiology of the PNS read as
a new book. The remainder of the first volume consists of
10 chapters that review the pathology, clinical neurophysiology, and quantitative evaluation of the PNS. The two chapters on pathological alterations in cell bodies and on quantitating severity of neuropathy represent important new
chapters. The other eight have the same authorship as in the
second edition but have undergone revision and updating. A
striking change with regard to the first volume is the elimination of 13 chapters that had been in the second edition, most
of which focused on experimental models for neuropathy.
Although eliminated as chapters in the third edition, much
of this material has been incorporated into the preceding
chapters with integration of the experimental model under
the neurobiological principle that it clarifies. For example, the
neurotoxic effects of P,P’-iminodipropionitrile
are discussed
under the control of axon caliber in the third edition, rather
than in a chapter on experimental models of motor neuron
degeneration as in the second edition.
The second volume includes 53 chapters on diseases of
the PNS, one on peripheral nerve surgery, and two on rehabilitation. Among these 56 chapters, 20 are written by new
authors, including six on topics that were not covered in the
second edition. These new chapters address motor neuropathies with persistent conduction block, nonmalignant sensory
ganglionopathies, pharmacological treatment of pain, and
neuropathies seen in human immunodeficiency virus infection, Lyme disease, and tropical myeloneuropathies. This
broader and more comprehensive coverage of peripheral
nerve disease by itself makes the third edition an important
new reference, even for those neurologists who have the
second edition. Eighteen other chapters have been rewritten
with new authors collaborating with previous ones, stimulating the broader coverage of topics. For example, the chapter
on hereditary motor sensory neuropathies now includes a
thorough discussion of genetic mechanisms and gene localizations for HMSN IA, IB, and X. The 18 chapters without
change in authorship have all undergone significant revision
and updating. Examples include discussion of anti-Hu antibodies in patients with small-cell lung carcinoma who have
sensory neuronopathy and the clear genetic distinction of
neurofibromatosis 1 and 2.
In addition to the changes in content, there are also pleasing changes in style. Each chapter starts with a page-referenced outline of its major and minor headings, facilitating
the reader’s rapid access to the relevant heading through an
additional mechanism besides the usual index.
In short, the third edition of Peripheral Neuropathy is an
important addition to the library of all neurobiologists who
have a serious interest in the PNS and all neurologists who
frequently care for patients with peripheral nerve disease,
even those who have the first and second editions.
Richard K.Olney, M D
Sun Francisco, C A
874 Copyright 0 1993 by the American Neurological Association
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periphery, low, illustrated, 335, dsc, griffin, vols, phd, john, philadelphia, saunders, frcp, 720, 1993, phillip, neuropathy, thomas, edited, joseph, dyck, peter, poduslo, james, cbe
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