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код для вставкиBehavioral Sciences and the Law Behav. Sci. Law 26: 413–434 (2008) Published online in Wiley InterScience (www.interscience.wiley.com) DOI: 10.1002/bsl.828 Treatment Outcomes for Female Offenders: Relationship to Number of Axis I Diagnoses Joann Y. Sacks, Ph.D.,*,y Karen McKendrick, M.P.H.,z Zachary Hamilton, M.A.,x { Charles M. Cleland, Ph.D., jj Frank S. Pearson, Ph.D. and Steven Banks, Ph.D.# This article describes a study that examined the relationship between multiple Axis I mental health diagnoses and treatment outcomes for female offenders in prison substance abuse treatment programs. Preliminary findings of the effectiveness of therapeutic community (TC) treatment, modified for female offenders, relative to a control cognitive behavioral treatment condition, are presented. The hypothesis—that participants who fit into multiple diagnostic categories have more dysfunctional symptoms and behaviors at baseline—was confirmed; however, a hypothesized relationship between the number of Axis I diagnoses and 6 month treatment outcomes across five domains (mental health, trauma exposure, substance use, HIV needle risk behaviors, and HIV sexual risk) was not supported. Across all Axis I mental health groups, TC treatment was significantly more effective than the control condition overall, as well as on measures of mental health symptoms and HIV sexual risk. These findings suggest that this TC treatment program, as modified, is an effective model for women with varied diagnoses and diagnostic complexities. Copyright # 2008 John Wiley & Sons, Ltd. *Correspondence to: Joann Y. Sacks, Ph.D., Center for the Integration of Research and Practice (CIRP), National Development and Research Institutes, Inc. (NDRI), 71 West 23rd Street, 8th Floor, New York, NY 10010, U.S.A. E-mail: [email protected] y Deputy Director. z Assistant Project Director, Center for the Integration of Research and Practice (CIRP). x Research Associate, Center for the Integration of Research and Practice (CIRP). ô Statistician, Center for the Integration of Research and Practice (CIRP). k Senior Principal Investigator, Center for the Integration of Research and Practice (CIRP). # Research Associate Professor of Psychiatry, University of Massachusetts Medical School. Copyright # 2008 John Wiley & Sons, Ltd. 414 J. Y. Sacks et al. BACKGROUND Co-occurring Disorders and their Relationship to Crime and Incarceration It is well documented that individuals with co-occurring substance use and mental disorders have a greater propensity to be involved with the criminal justice system, and hence are more likely to become incarcerated (Drake, Xie, McHugo, & Shumway, 2001; James & Glaze, 2006; McNeil, Binder, & Robinson, 2005; Monahan et al., 2001, 2005; Regier et al., 1990; Sacks, Sacks, De Leon, Bernhardt, & Staines, 1997) and tend to re-enter the correctional system once released to the community (Messina, Burdon, Hagopian, & Prendergast, 2004; Peters, LeVasseur, & Chandler, 2004). Among a community-based sample of individuals with cooccurring drug abuse and mental illness, Sacks and colleagues (1997) found that nearly all participants (99%) had some criminal involvement, with 86% having at least one arrest and 59% having at least one conviction, and on average 4.1 years of prior incarceration[s]. The provision of required treatment services to incarcerated individuals with cooccurring disorders represents a substantial challenge to treatment and correctional systems (Kubiak, 2004; Sacks, Sacks, McKendrick, Banks, & Stommel, 2004a). In a previous analysis, Sacks and colleagues (2008) described such an offender population, revealing several deficit/need areas related to employment, education, residential stability, and criminality, in addition to services related to psychological symptoms and substance use. Correctional treatment programs often lack the resources required to address this complexity of offender needs adequately; in the absence of such treatment and post-prison community supports, offenders with cooccurring disorders are more likely to be reincarcerated than those with substance use problems alone (Messina et al., 2004). Gender, Co-occurring Disorders, and Offenders The prevalence of behavioral health disorders differs by gender both for the general population and within the criminal justice system. Robins and Regier (1991) estimated that approximately 20% of men and women in the general population had an active disorder; however, men experienced higher rates of antisocial personality disorder and substance abuse disorders compared with women, who were more likely to have mood disorders, including depression, generalized anxiety, panic, phobia, and somatic disorders. This pattern is especially evident for substanceabusing men and women. Compared with their male counterparts, substanceabusing women were almost four times more likely to have major depression with co-occurring alcohol abuse, three and a half times more likely to have co-occurring panic disorder, and more than twice as likely to have phobic disorder (Blume, 1990). Rates of mental disorders are higher within prison populations than in the general population, and female offenders are more likely than male offenders to be diagnosed with a mental disorder (Ditton, 1999; Peters, Strozier, Murrin, & Kearns, 1997). Bloom and Covington (2000) reported that female offenders were more likely to use serious drugs, to use them more frequently, to inject drugs, and to have a co-existing Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 415 psychiatric disorder compared with male offenders. An assessment of co-occurring disorders for inmates needing or receiving mental health treatment while in prison reported 40% of male inmates with at least one Axis I disorder and an active addiction disorder compared with 57% of female inmates (Blitz, Wolff, Pan, & Pogorzelski, 2005). In addition, although 59% of women entering prison had at least one mental disorder (excluding substance abuse/dependence), prison screening identified only slightly over one-third (Parsons, Walker, & Grubin, 2001), which indicates that the presence of mental disorder among women in the criminal justice system may be under-reported. Compared with men, female prisoners were more likely to report depression, anxiety, low self-esteem, and use of prescribed medications for psychological problems (Peters et al., 1997). Similarly, Langan and Pelissier (2001) identified several problem areas that are more prevalent among incarcerated women as compared with men, including poor physical health, lack of education, and a troubled childhood/family environment. Female Offenders with Co-occurring Disorders The patterns of co-occurring disorders among women in criminal justice systems are similar to, but more severe than, those found for women in community-based treatment studies (Sacks, 2004). Female inmates, compared with women in community epidemiologic studies, have elevated rates of substance use and mental health disorders, including substance abuse and dependence, mood disorders, borderline personality, and PTSD (Jordan, Schlenger, Fairbank, & Caddell, 1996; Maden, Swinton, & Gunn, 1994; Teplin, Abram, & McClelland, 1996). Women in prison, as well as in community-based substance abuse treatment, report high rates of exposure to physical and sexual assault, including childhood abuse, and many exhibit symptoms of posttraumatic stress disorder (PTSD); estimates of the rate of PTSD among women with substance use disorders range from 30 to 59 percent (Brown, Recupero, & Stout, 1995). Women with PTSD have poor retention and outcomes in substance abuse treatment (Hien, Cohen, Miele, Litt, & Capstick, 2004; Hien & Scheier, 1996; Zweben et al., 2004). A recent study found that many offenders who need or receive mental health treatment while in prison have multiple Axis I diagnoses, and that the clusters of diagnoses differ by gender (Blitz et al., 2005). These data have implications for the gender-specific treatment needs of female offenders. Current correctional substance abuse treatment programs are often not designed to meet the complex array of problems typical of offenders with co-occurring disorders (Peters et al., 2004), and fewer still are designed to meet the specialized treatment needs of female offenders (Grella, Stein, & Greenwell, 2005; Hills, 2003; Mullings, Marquart, & Hartley, 2003). Some treatment models have been developed for offenders with particular diagnoses (Najavits, 2003), but none have taken into consideration that the diagnosed disorder may be part of a complex Axis I mental health diagnostic profile, creating a need for a different approach to treatment. The degree to which more sophisticated diagnostic assessment can identify the presence of multiple Axis I mental health diagnoses for an individual has important implications for the provision of effective treatment interventions. Comprehensive prison treatment programs for men, with integrated mental health and substance abuse treatment for Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 416 J. Y. Sacks et al. co-occurring disorders, can reduce recidivism and improve post-prison substance use outcomes (Sacks et al., 2004a), but little research has examined the efficacy of such programs for the female offender with a complex Axis I diagnostic profile. Effectiveness of Therapeutic Community Treatment for Substance-Using Offenders Despite the extensive service and treatment needs of offender populations, effective programs have been identified. Therapeutic community (TC) treatment has proven to be effective across a variety of populations and settings, including in the community (see, e.g., De Leon, 1984; Hubbard, Rachal, Craddock, & Cavanaugh, 1984; Simpson & Sells, 1982) and in prisons (see, e.g., Hser, Anglin, & Powers, 1993; Wexler, Falkin, & Lipton, 1990). A modified TC, developed for male offenders with co-occurring severe mental illness and substance use disorders, demonstrated significantly greater reductions in reincarceration rates and substance use compared with a mental health control group (Sacks et al., 2004a; Sullivan, McKendrick, Sacks, & Banks, 2007). In the parent study (Sacks et al., 2008) to the research reported here, a modified TC developed for female offenders with co-occurring severe mental illness and substance use disorders showed significantly better 6 month post-prison outcomes for participants randomly assigned to the prison modified TC, compared with those assigned to a control condition (i.e. cognitive behavioral treatment) on measures of criminal activity (arrests), HIV sexual-risk behavior, and mental health (depression, and post-traumatic symptom severity). To develop the most effective prison treatment options for female offenders with substance use, more needs to be understood about the clusters of Axis I mental health disorders that co-occur with their substance use/abuse and the extent to which the number of co-occurring Axis I mental health diagnoses is related to successful response to treatment. The Study Although recent research has established the importance of prison treatment for cooccurring disorders, and has provided evidence that specific mental health diagnoses may impede response to substance abuse treatment, studies have not differentiated treatment outcomes for those offenders with a complexity of multiple Axis I diagnoses. The study reported in this article examined the functioning of female offenders with substance use disorders and a range of Axis I diagnoses, and evaluated offender functioning and treatment response in relation to diagnostic complexity. Three critical issues have an impact on female criminal etiology and treatment success: mental health, substance abuse, and trauma. While these issues are linked, historically, each has been examined separately, and little research has considered the combined or additive effect (e.g. Blitz et al., 2005). The study reported in this article uses data from a subset of participants for whom diagnostic information was available to identify disparities and dysfunction associated with multiple mental diagnoses at baseline and to explore the extent to which the number of co-occurring Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 417 Axis I mental health diagnoses affected the effectiveness of correctional treatment delivered to female offenders with substance use problems. This paper uses the term ‘‘diagnostic complexity’’ to denote multiple Axis I mental health diagnoses. Hypothesis 1 of the study was that the number of Axis I mental diagnoses would be associated with greater symptomatic and behavioral dysfunction at baseline. The moderating effects of multiple Axis I psychiatric disorders on the responsiveness of female offenders to prison TC treatment, compared with a less intense control condition (cognitive behavioral treatment), was also investigated. The expectation of this study was that an increase in the number of Axis I psychiatric disorders would increase the challenges of treating patients. Hypothesis 2 was that, despite significant treatment effects associated with the TC condition, participants with more Axis I diagnoses would report comparatively less improvement at 6 months post-prison release. Hypothesis 3 was that the TC condition, which addresses emotional coping skills as an integral component of the program (the comparison cognitive behavioral program did not contain a comparable component), would produce more positive treatment effects for participants with greater diagnostic complexity. METHOD Research Design The analyses reported in this article included the subset of participants who had been randomly selected at baseline to complete Modules A, D, E, F, G, L, and P (demographic information, generalized anxiety disorder, PTSD, depressive disorder, manic/hypo manic, ADD/ADHD, and ASP-adult) of the Diagnostic Interview Survey (DIS-IV; Robins, Cottler, Bucholz, & Compton, 1995). Disparities and dysfunction at baseline were assessed followed by an investigation of 6 month post-prison outcomes. This paper discusses analyses of the number of Axis I DSMIV mental diagnoses, as a measure of diagnostic complexity, in relation to profiles at intake and to treatment outcomes at 6 months post-prison release. The number of Axis I mental diagnoses was expected to be associated with greater symptomatic and behavioral dysfunction at intake across five domains (i.e. mental health, trauma exposure, substance use, HIV needle risk behaviors, and HIV sexual risk). Examination of 6 month post-prison outcomes in relation to the number of Axis I diagnoses will add to our understanding of the nature of co-occurring disorders and treatment engagement for this population of incarcerated women. The primary aim of this research was to test two hypotheses: (1) that, despite significant treatment effects associated with the TC condition, participants with more diagnoses would report comparatively less improvement at 6 months post-prison release across the same five domains; and (2) that the TC condition would produce more positive treatment effects for participants with greater mental health diagnostic complexity compared with the control condition. Research Procedures The study employed a prospective, longitudinal, repeated measures design to evaluate participants at five points: baseline (entry into prison treatment); prison Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 418 J. Y. Sacks et al. discharge; 6 months post-prison release; 12 months post-prison release; and 18 months post-prison release. Eligibility criteria required that study participants have (1) at least 6 months (and no more than 24 months) remaining until parole eligibility, (2) a Colorado Department of Corrections (CDOC) Standardized Offender Assessment (CDOC, 2004) substance abuse score indicative of serious substance abuse problems requiring substance abuse treatment, and (3) a security risk level classification of minimum, minimum-restricted, or medium to permit participation in treatment. Within the first month of admission to the Denver Women’s Correctional Facility (DWCF), eligible inmates were contacted by a trained and experienced interviewer, who explained the study and who obtained the informed consent of the women who volunteered to participate in the research. Female inmates who consented to participate in the research at prison entry (baseline) were randomly assigned to one of two treatment conditions, E[xperimental] (an experimental TC) or C[ontrol] (cognitive behavioral treatment). Sample Of the 584 female inmates who entered the study, 220 (37.7%) were randomly selected to complete selected modules of the DSM-IV DIS-IV. A total of 193 who completed the DIS-IV were eligible for a 6 month post-prison discharge interview. This study included 147 (147/193 ¼ 76.2%) inmates who were retrieved and who completed a 6 month post-prison discharge interview. The reasons that 46 women were not retrieved were that one had deceased, 17 refused, 24 were not located within the acceptable time period, and 4 participants were scheduled but not yet interviewed. Only three significant profile differences emerged when comparing participants retrieved at 6 month post-prison release to those not retrieved. The retrieved sample was more likely to report having sex with an intravenous drug user in the last 6 months (23.1 versus 7.1%; p < 0.03), was less likely to have an Attention Deficit/Hyperactivity disorder (ADHD; 10.9 versus 28.6%; p < 0.01), and was less likely to report running away from home (56.9 versus 76.2%; p < 0.03). Two significant differences emerged for participants randomly selected to complete the DIS-IV compared with those not selected; specifically, participants who completed the DIS-IV sections were more likely to have a high school diploma or GED ( p < 0.03) and reported more symptoms on the BDI total ( p < 0.04). Treatment Interventions Both treatment conditions provided intensive substance abuse and mental health treatment services within the prison; however, E services were integrated within the TC treatment program, whereas C services were delivered as separate, discrete interventions. The Therapeutic Community (TC)–Experimental (E) Condition The experimental TC is a 6–9 month program located in a separate 72-bed unit within the prison. Inmates progressed through four program stages with upper level inmates Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 419 functioning as peer mentors for newer members. The comprehensive TC treatment program focused on increasing awareness and understanding female roles and relationships as they relate to addiction and drugs used and abused, and emotional and behavioral coping skills. Program elements addressed issues of substance abuse, relapse prevention, mental health, criminal thinking and behavior, coping with trauma and abuse, and parenting skills. All staff received special training related to working with women exposed to trauma and abuse, making the program ‘‘trauma informed’’ and ‘‘trauma sensitive.’’ In addition, the women participated in three facility-wide services: mental health (psychiatric assessment, medication, individual counseling), education (GED and Adult Basic Education classes), and health care (medical and dental treatment). On average, study participants remained in the program 6.5 months. Formal program activities (individual and group interventions), took place 5 days each week for 4 hours each day; women also worked in correctional industries 4 hours/day. The Intensive Outpatient Program (IOP)–Control (C) Condition The comparison intervention, called Intensive Outpatient Treatment (IOP) at the prison, was designed to address substance abuse and criminality, with a focus on prevention of relapse and recidivism. The IOP substance abuse treatment curriculum consisted of a 90 hour manualized course (Strategies for Self-Improvement and Change, Wanburg & Milkman, 1998), utilizing a cognitive behavioral format to address underlying issues of substance use/abuse and criminal behavior. The course was completed within 15 weeks. The IOP women also received facility-wide mental health services (psychiatric assessment, psychotropic medication, and individual counseling), education (GED and Adult Basic Education classes) and health care (medical and dental treatment) and had access to parenting and other classes offered by the prison. Inmates in the IOP attended classroom activities 2 days per week for 2 hours each day, and worked in correctional industries daily, except when attending classes. Overall, women in the IOP (C group) received their services in approximately 6–9 months. Data Collection Measures Reported data were collected at baseline (prison treatment entry) and at 6 months post-prison release using standardized self-report instruments, administered by a research associate to all participants in face-to-face interviews; additional data were obtained from CDOC computerized information system sources. On average, baseline interviews took two and a half hours to complete. Participants were given monetary compensation of $35 for the baseline interview and $25 for the follow-up interview. The self-report instruments have all proven to be appropriate and effective in a variety of ethnic, gender, and cultural contexts (see, e.g., Sacks, Banks, McKendrick, & Sacks, 2008a; Sacks et al., 2008b; Sacks, Sacks, & De Leon, 1999; Sacks et al., 2004a, 2004b). The Center for Therapeutic Community Research (CTCR) Baseline Protocol (CTCR, 1992) was adapted from the TCU Drug Abuse Treatment Assessment Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 420 J. Y. Sacks et al. Research (DATAR) intake form, the Addiction Severity Index (ASI) (McLellan, Alterman, Cacciola, Metzger, & O’Brien, 1992), and the TCU AIDS Risk Assessment (Simpson, 1997). The CTCR protocol assesses socio-demographic/background variables (age, sex, ethnicity, health, education, employment, parenting, peer and family support, and housing), self-reported lifetime and current substance use, criminal behaviors, and HIV-risk behaviors. The CTCR Baseline Protocol also gathers information regarding perceived psychological symptoms (e.g. prevalence of suicidal thoughts and actions) and treatment history including inpatient and outpatient treatment for psychological problems and substance use. Same day, alternate forms reliability for alcohol and nine drug categories, measured in terms of percent exact agreement, averaged 94% (range 82–100%) in a similar sample of women (Sacks et al., 1999). Intake data were collected for lifetime and activity/status in the 6 months prior to incarceration. Community follow-up interviews reported activity/status in the 6 months post prison exit. Substance use and related problems were assessed using self-reported information about the historic and current frequency of use of alcohol, nine categories of illegal drugs, and historic and current substance abuse treatment. HIV/AIDS risk was assessed using self-reported information on needle risk and sexual risk behaviors. Needle risk included measures of any intravenous drug use. HIV sexual risk practices included two measures: exchanging sex for money or drugs, and having unprotected sex with two or more male partners. Psychiatric Diagnosis The Diagnostic Interview Schedule (DIS-IV) (Robins et al., 1995) is a structured clinical interview that generated DSM-IV lifetime and current psychiatric and substance abuse/dependence diagnoses. Seven diagnostic modules (A, D, E, F, G, L, P) were administered at baseline to a sub-sample of 220 participants to estimate the prevalence of co-occurring disorders in the study sample. Modules from the DIS-IV were administered, rather than the entire interview, to minimize baseline interview time. The Axis I modules were selected on the basis of reported prevalence in the system (Stommel, personal communication, September 8, 2001). Diagnoses from other modules (e.g. schizophrenia, personality disorders) were not assessed, and inmates with such disorders were expected to be intermixed within both treatment conditions. Psychological Symptoms/Functioning and Exposure to Trauma Information on psychological symptoms and functioning, and exposure to trauma or abuse, was gathered from four sources, as described below. The Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) was used to assess domains of depression consistent with the DSM-IV criteria for depressive disorders. The Brief Symptom Inventory (BSI; Derogatis, 1993) is a shortened, revised version of the Symptom Checklist Revised-90 (Derogatis, 1977), which provides a measure of nine domains of mental health symptoms and a global index of distress, the Global Severity Index (GSI). Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 421 The Posttraumatic Symptom Severity Scale (PSS) of the Post-traumatic Stress Diagnostic Scale (PDS; Foa, Cashman, Jaycox, & Perry, 1997) was used to assess the severity of post-traumatic stress disorder (PTSD) symptoms in a classification schema corresponding to DSM-IV PTSD symptoms (‘‘Re-experiencing,’’ ‘‘Avoidance,’’ ‘‘Arousal’’). The PTSD symptom severity score can range from 0 to 51, with higher scores on the PSS corresponding to greater severity of post-traumatic stress symptoms. The Trauma History Questionnaire (THQ; Green, 1996) measured lifetime, recent, and childhood (under age 14) exposure to community, physical, and sexual trauma and abuse. Test/retest reliability of the 65 THQ items (over 2–3 months) ranged from 0.47 to 1.00 (average 0.65) (Green et al., 2000). Analytic Plan Descriptive analyses were conducted to investigate baseline differences by diagnostic complexity as required to test Hypothesis 1. Table 1 shows many variables of interest, arranged according to the number of diagnoses (dx) collapsed into four groups: no DSM-IV Axis I diagnosis (0dx), one diagnosis (1dx), two or three diagnoses (2–3dx), or four or more diagnoses (4þdx). The degree of equivalence between the four groups at baseline was assessed using chi-square and one-way ANOVA analyses. An intent-to-treat analysis of change from baseline to 6 months post-prison release was conducted for five key outcome domains: mental health (BDI total, GSI total, PSS trauma severity index), trauma exposure (THQ any physical violence, THQ any sexual violence), substance use (any drug use, severity of drug use), HIV needle risk (any intravenous drug use), and HIV sexual risk (any exchange of sex for money/drugs, unprotected sex with more than two male partners). Z-scores were computed for the ten outcome measures, then averaged within each domain; for example, Z-scores for the GSI, BDI-II Total, and PSS were averaged to create a composite outcome score for mental health. To control for activity/status at intake, baseline data were used to compute Z-scores for the ten outcomes and composite scores. Z-scores were computed so that a higher score meant more activity or greater severity reported. To address Hypothesis 2, the relationship between the number of DSM-IV Axis I diagnoses and outcomes at the 6 month follow-up assessment was evaluated using multivariate analysis of covariance (MANCOVA). The main effect for treatment (independent variable) was assessed for the composites of the five outcome domains (dependent variables), controlling for the number of diagnoses and the baseline equivalents of the outcome measures (covariates). In accordance with the findings of the earlier report (Sacks et al., 2008), a significant treatment effect favoring the TC condition was expected at the 6 month follow-up; a significant difference was also expected in the number of DSM-IV Axis I diagnoses, indicative of a negative relationship between the number of diagnoses and the degree of improvement. Finally, the interaction between treatment condition and number of diagnoses was examined to test whether, compared with the control condition, the TC (E) condition would generate more positive treatment effects for those participants whose mental health diagnostic status was more complex. Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 422 J. Y. Sacks et al. Table 1. Comparison of 147 female offenders by number of DIS-IV diagnoses (Hypothesis 1) DSM-IV diagnosis1 Major depression PTSD Generalized anxiety Manic/hypomanic Bipolar I/II ADD/ADHD Demographics Age Race Caucasian African American/Black Hispanic Other Marital status—never married High-school diploma/GED L6 number of residences Family history Parent use/abused substance Parent had mental health problem Ran away Criminality Age first illegal activity Age first prison incarceration LT number of arrests LT sex offense (prostitution) Mental health Beck Depression Total Brief Symptom Index Brief Symptom Index 63þ Post-Traumatic Symptom Severity Post-Traumatic Symptom 36þ LT attempted suicide LT inpatient mental health tx Current psychiatric medication Trauma/abuse LT trauma/abuse exposure LT sexual violence L6 trauma/abuse exposure L6 community violence L6 physical violence L6 sexual violence Trauma/abuse before age 14 Substance use Age first alcohol use Age first drug use LT number types of drug used LT opiate use L6 alcohol use L6 frequency of alcohol use2,3 L6 drug use L6 sum frequency of drug use4 HIV—needle risk behaviors LT intravenous drug use L6 intravenous drug use 0dx (N ¼ 40) %/mean (std) 1dx (N ¼ 29) %/mean (std) 2–3dx (N ¼ 48) %/mean (std) 4þdx (N ¼ 30) %/mean (std) p 0.0 0.0 0.0 0.0 0.0 0.0 62.1 20.7 10.3 6.9 0.0 0.0 87.5 70.8 31.3 16.7 16.7 14.6 100.0 73.3 66.7 100.0 100.0 30.0 .000*** .000*** .000*** .000*** .000*** .000*** 34.7 (8.1) 35.3 (8.8) 36.5 (6.9) 34.4 (8.2) .645 47.5 15.0 32.5 5.0 35.0 70.0 2.0 (1.7) 37.9 24.1 20.7 17.2 20.7 72.4 1.7 (1.9) 52.1 12.5 20.8 14.6 25.0 68.8 2.0 (1.7) 46.7 26.7 16.7 10.0 30.0 63.3 3.1 (3.0) .479 .458 .892 .031* 55.0 20.5 43.6 59.3 17.2 55.2 78.7 38.3 58.7 64.3 40.0 73.3 .108 .074 .101 13.7 (5.2) 13.3 (3.7) 12.1 (3.4) 12.4 (4.8) 31.4 (8.1) 30.8 (8.6) 32.1 (7.2) 29.2 (7.8) 10.0 (15.0) 12.0 (12.5) 13.9 (11.2) 12.7 (10.2) 7.5 31.0 33.3 50.0 .305 .449 .453 .001*** 12.7 (8.1) 51.6 (9.5) 10.0 8.1 (9.0) 0.0 20.0 12.5 2.5 .000*** .000*** .000*** .000*** .002** .026* .000*** .000*** 16.9 (10.8) 20.8 (11.3) 23.4 (11.2) 56.1 (11.7) 61.2 (10.2) 63.9 (6.9) 20.7 47.9 66.7 12.5 (9.8) 19.7 (13.2) 22.9 (13.1) 3.4 20.8 24.1 27.6 37.5 53.3 17.2 35.4 66.7 24.1 47.9 43.3 95.0 55.3 57.5 50.0 30.0 7.5 72.5 100.0 62.1 62.1 62.1 37.9 17.2 48.3 97.9 85.4 75.0 64.6 56.3 20.8 64.6 100.0 96.6 83.3 76.7 60.0 43.3 80.0 .394 .000*** .077 .149 .026* .003** .057 14.7 (4.3) 17.1 (6.4) 3.1 (1.8) 15.0 42.5 3.1 (2.1) 57.5 6.7 (4.2) 15.3 (4.0) 16.3 (4.4) 3.4 (1.4) 24.1 48.3 4.1 (2.3) 62.1 7.4 (5.0) 13.7 (3.3) 15.0 (4.6) 4.2 (1.9) 43.8 52.1 4.7 (2.6) 68.8 11.5 (5.8) 13.4 (5.8) 15.0 (3.3) 4.0 (1.9) 40.0 73.3 4.7 (2.9) 80.0 10.7 (6.4) .269 .196 .028* .020* .071 .198 .233 .004** 37.5 20.0 34.5 13.8 56.3 29.2 60.0 36.7 .074 .167 (Continues) Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 423 Table 1. (Continued) 1 DSM-IV diagnosis HIV—sexual risk behaviors LT sex for money/drugs L6 sex for money/drugs L6 unprotected sex with 2þpartners 0dx (N ¼ 40) %/mean (std) 1dx (N ¼ 29) %/mean (std) 2–3dx (N ¼ 48) %/mean (std) 4þdx (N ¼ 30) %/mean (std) 20.0 12.5 12.8 34.5 13.8 10.7 39.6 20.8 22.9 56.7 30.0 30.0 p .017* .255 .173 dx ¼ diagnosis; LT ¼ lifetime; L12 ¼ last 12 months; L6 ¼ last 6 months; tx ¼ treatment. *p < 0.05; **p < 0.01; ***p < 0.001. 1 Table reports DSM-IV diagnoses assessed at baseline. 2, Based on a reduced sample of participants who used alcohol: 0dx (n ¼ 17), 1dx (n ¼ 14), 2–3dx (n ¼ 25), 4þdx (n ¼ 22). 3 Frequency codes of substance use: 0 ¼ no use, 1 ¼ once, 2 ¼ a few times, 3 ¼ once a month, 4 ¼ once every two weeks, 5 ¼ once a week, 6 ¼ several times a week, 7 ¼ every day, 8 ¼ more than once a day. 4 Based on a reduced sample of participants who used drugs: 0dx (n ¼ 23), 1dx (n ¼ 18), 2–3dx (n ¼ 33), 4þdx (n ¼ 24). An exploratory analysis was conducted into the equivalency of treatment effects by the number of diagnoses (Hypothesis 3). Hedge’s g effect sizes were computed to assess differential treatment effects for clients with zero, one, two or three, and four or more Axis I diagnoses. The E group was expected to report greater improvement compared with C for each level of Axis I diagnosis. Effect sizes were scaled so that positive effects indicated greater improvement for the E group, compared with the C group, from baseline to the 6 month follow-up assessment. A one-sample t-test was used to determine whether the average effect was significantly greater than zero. RESULTS Profiles Table 1 addresses Hypothesis 1 by presenting demographic and background data for inmates in the four diagnostic groups. The majority (72.8%) of female offenders, all of whom had been designated to receive substance abuse treatment, had at least one Axis I mental health diagnosis. Participants were organized into four diagnostic categories, according to their DSM-IV Axis I diagnoses: (1) no diagnosis (0dx; 27.2%); (2) one diagnosis (1dx; 19.7%); (3) two or three diagnoses (2–3dx; 32.7%); and (4) four or more diagnoses (4þdx; 20.4%). The diagnostic profiles of the study participants, shown in Table 1, revealed that major depression was the most prevalent disorder overall (62.1, 87.5, and 100.0% for groups with ‘‘1,’’ ‘‘2 or 3,’’ and ‘‘4 or more’’ diagnoses, respectively), followed by PTSD (20.7, 70.8, and 73.3% for groups with ‘‘1,’’ ‘‘2 or 3,’’ and ‘‘4 or more’’ diagnoses, respectively). Demographic and Background Characteristics Significant differences by number of diagnoses were not detected for age, race/ ethnicity, marital status, education, or measures of family history. Participants in the Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 424 J. Y. Sacks et al. ‘‘4 or more’’ diagnoses group had lived in more residences immediately prior to incarceration ( p < 0.04), and had more lifetime sexual offenses ( p < 0.001) than participants with fewer diagnoses. The vast majority of measures for criminality, including measures of onset, incarceration, arrest, and criminal activity, revealed no differences among the groups. Mental Health The three standardized measures of psychological symptoms (BDI-II Total, BSI, and the PSS Scale) all showed that an increase in the number of Axis I diagnoses had a significant linear relationship with symptom severity (Table 1). Comparing the group with no (‘‘0’’) diagnosis and the group with ‘‘4 or more’’ diagnoses revealed consistently higher values for the latter group; specifically, the average BDI score of 12.7 (sd ¼ 8.1) for the ‘‘0’’ diagnosis group increased to 23.4 (sd ¼ 11.2) for the ‘‘4 or more’’ diagnoses group, the BSI of 51.6 (sd ¼ 9.5) increased to 63.9 (sd ¼ 6.9), and the PSS of 8.1 (sd ¼ 9.0) increased to 22.9 (sd ¼ 13.1). This pattern was repeated in the proportion of participants who scored in the clinical range on the BSI (63 or higher), which increased from 10.0 to 20.7 to 47.9 to 66.7% for the four groups (‘‘0,’’ ‘‘1,’’ ‘‘2 or 3,’’ and ‘‘4 or more’’ diagnoses, respectively; p < 0.001), as well as in the percent of participants with a ‘‘severe’’ PSS score (36 or greater), which was 0.0% in the ‘‘0’’ diagnosis group, increasing to 24.1% in the ‘‘4 or more’’ diagnoses group ( p < 0.002). The symptom profiles mirrored the increasing diagnostic prevalence of depression and PTSD that occurred as the number of Axis I diagnoses increased; the prevalence of attempted suicide (lifetime) ranged from 20.0% for the ‘‘0’’ diagnosis group to 53.3% for the ‘‘4 or more’’ diagnoses group ( p < 0.03). Trauma Exposure Virtually all (98.0%) participants reported exposure to some form of trauma during their lifetime, especially community violence (95.9%) and physical violence (95.9%); 66.7% of the women indicated exposure to trauma prior to age fourteen. These measures showed no statistical differences by number of Axis I diagnoses. The statistical differences that were detected indicated greater exposure to lifetime and recent interpersonal violence (physical and sexual violence) for participants with more Axis I diagnoses. Exposure to sexual violence, which was 55.3% for those with no Axis I diagnosis, increased to 96.6% for those with four or more diagnoses ( p < 0.001). Thirty percent of inmates with no Axis I diagnosis reported physical violence in the 6 months prior to incarceration; this proportion doubled to 60.0% for inmates with four or more diagnoses ( p < 0.03). Substance use All offenders who participated in the study were substance users as designated by the CDOC assessment, which evaluates the severity of historic and current drug use behavior and drug-related crime. A linear relationship was observed between the Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 425 number of Axis I mental health diagnoses and use of more types of illegal drug (lifetime), use of opiates (lifetime), and frequency of drug use prior to prison admission. HIV Risk Behaviors A linear pattern was again detected for lifetime HIV sexual-risk behavior. Participants with more psychiatric diagnoses were more likely to report having sex for money or drugs (lifetime). Differences were not detected among the groups on measures of needle use or sexual activity in the 6 months prior to incarceration. Outcomes at 6 Months Post-prison Release Results for the MANCOVA analysis to address Hypothesis 2 are presented in Table 2. Contrary to the hypothesis, the number of DSM-IV Axis I diagnoses was not related to improvement at follow-up. With respect to Hypothesis 3, testing of the interaction between treatment condition and the number of diagnoses also showed divergent results. A significant treatment main effect did emerge, favoring the E condition ( p < 0.02), overall and specifically for the domains of mental health ( p < 0.01) and HIV sexual risk behavior ( p < 0.03). Although the interaction term between treatment group and number of mental diagnoses was not significant, Table 3 presents results of follow-up, exploratory analyses using Hedge’s g effect sizes to assess differential treatment effects for clients with ‘‘0,’’ ‘‘1,’’ ‘‘2 or 3,’’ and ‘‘4 or more’’ Axis I diagnoses. Hedge’s g effects were scaled so that a positive effect would indicate greater improvement for the E group, compared with the C group, from baseline to 6 months post-prison release. As shown in Table 3, all but one of the domain level effects was positive, indicating greater improvement for the E condition, compared with the C group, from baseline to 6 months post-prison release. These findings support those found in an earlier report of preliminary analyses (Sacks et al., 2008). The differences in the Hedge’s g effects for the ‘‘4 or more’’ diagnoses group, although sizable, did not produce a significant interaction effect; therefore, the difference could be the result of simple random variation. Table 2. MANCOVA results (Hypothesis 2) Main effects Domain-level effects Mental health Interpersonal violence Drug use HIV needle risk HIV sexual risk E (n ¼ 90) Z-score mean (std) C (n ¼ 57) Z-score mean (std) — — 0.252 (0.750) 0.193 (0.583) 0.156 (0.653) 0.059 (0.863) 0.183 (0.374) — — 0.023 (0.845) 0.033 (0.866) 0.046 (0.807) 0.051 (0.704) 0.018 (0.807) E vs. C Partial eta sq. ( p) 0.097 (.016*) 0.063 0.024 0.008 0.000 0.037 (0.003**) (0.068) (0.286) (0.873) (0.023*) No. of diagnoses Partial eta sq. ( p) 0.008 (.958) 0.000 0.002 0.000 0.002 0.001 (0.864) (0.612) (0.809) (0.629) (0.750) *p < 0.05; **p < 0.01. Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 426 J. Y. Sacks et al. Table 3. Hedge’s g effect sizesy —E versus C treatment effects by number of Axis I mental disorders (Hypothesis 3) Mental health composite BDI total score BSI global severity PSS trauma severity index Trauma exposure composite Physical violence Sexual violence Substance use composite Any drug use Sum freq. drug use HIV needle risk composite HIV sexual risk composite Sex for money/drugs Unprotected sex w/2þ 0dx (24 E & 16 C) Hedge’s g 1dx (20 E & 9 C) Hedge’s g 2–3dx (28 E & 20 C) Hedge’s g 4þdx (18 E & 12 C) Hedge’s g 0.295 0.341 0.397 0.147 0.026 0.146 0.198 0.049 0.086 0.012 0.156 0.181 0.328 0.033 0.249 0.272 0.309 0.167 0.009 0.085 0.103 0.045 0.048 0.041 0.016 0.285 0.262 0.308 0.021 0.189 0.093 0.033 0.071 0.000 0.141 0.013 0.031 0.057 0.000 0.040 0.017 0.063 0.384 0.473 0.296 0.384 0.321 0.398 0.243 0.172 0.129 0.214 0.137 0.112 0.177 0.047 y Positive Hedge’s g effects indicate greater improvement for the E group compared with C from baseline to 6 month post-prison release. dx ¼ diagnosis. DISCUSSION Summary of Findings Over three-quarters of the female, substance-abusing offenders in this study had at least one Axis I mental health diagnosis; since the study population consisted only of those women identified as needing substance abuse treatment, it provides important confirmation that women in prison with substance abuse problems are highly likely to have a co-occurring serious mental disorder. Over half of the participants had two or more Axis I serious mental health diagnoses and, within this group, over 70% had a diagnosis of major depression combined with PTSD. In particular, PTSD affects interpersonal interactive styles, which may have a negative impact on the offender’s ability to respond to the interpersonal therapeutic modalities; indeed, in communitybased studies, women with PTSD were more likely to have poor post-treatment outcomes. As hypothesized, an increase in the number of Axis I mental health diagnoses was characterized by a symptom and behavioral profile of increasing severity. It was anticipated that Axis I mental health diagnostic complexity, and the associated symptom severity, would result in poorer post-treatment outcomes; however, this was not confirmed. It was further hypothesized that TC treatment would prove to be a more effective treatment approach than the comparison cognitive behavioral program for women with more complex diagnoses; in the current study, the prison TC treatment, as modified for female offenders, was more effective than the comparison treatment across all diagnostic groups. Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 427 Multiple Diagnoses Few studies have explored the complexity of diagnostic profiles of women in prison and related these to prison treatment outcomes. In this age of diminishing resources for all treatment, including offender services, understanding the risk factors for relapse and recidivism among substance abusers in prison and the effectiveness of treatments for specialized offender sub-populations can guide the efficient use of treatment resources. This study demonstrates that female inmates who enter prison with a history of chronic and severe substance use and substance-related crimes are highly likely to have a co-occurring mental disorder, and that a significant percentage of these will be Axis I severe mental health disorders; indeed, the study revealed that such women are likely to have multiple Axis I psychiatric disorders. Furthermore, an increase in the number of diagnoses elevated the probability that PTSD would be present. In particular, PTSD affects interpersonal interactive styles, which could have a negative impact on the offender’s ability to respond to the interpersonal therapeutic modalities; indeed, in community-based studies, women with PTSD were more likely to have poor post-treatment outcomes. An earlier study (Blitz et al., 2005) demonstrated that, among women who the correction system identified as needing or receiving prison mental health services, 23% had additional co-occurring Axis I mental health diagnoses, according to prison-system assessments and diagnoses. The present study expands our understanding of the prevalence and nature of cooccurring multiple Axis I mental health disorders for female offenders by extending the population under study to female offenders identified as needing substance abuse treatment, and by determining diagnoses using an independent research instrument (DIS-IV), rather than relying on diagnoses that may have been more subjectively determined by multiple diagnosticians within the correctional setting. In this report, 73% of the female offenders with substance use/abuse also had an Axis I diagnosis, and over half (53%) had multiple Axis I diagnoses. The current findings are consistent with the literature for prevalence of any mental disorder among participants in community-based substance abuse treatment programs and suggest greater prevalence of severe mental disorders among female offenders in prison substance abuse treatment programs, as compared with mixed gender samples from community-based treatment programs (Compton et al., 2000; Sacks et al., 1997). The cumulative profile for this sample of female offenders supports using the number of Axis I diagnoses as a proxy for diagnostic severity. Of the women with two or three Axis I mental health diagnoses, almost all (88%) had a diagnosis of major depression, and over 70% had PTSD. Of the women with four or more diagnoses, all had diagnoses of major depression, manic/hypomanic, and bi-polar disorder; nearly three-quarters had a concurrent diagnosis of PTSD. Multiple psychiatric diagnoses were associated with increased severity and complexity of several mental health symptoms. These findings have important implications for treatment planning and for delivery of treatment services to female offenders with substance use problems. The complex needs of female offenders have been widely documented in the literature. Treatment models that focus on only one diagnosis may not sufficiently address the needs of women with two or three different psychiatric diagnoses; more comprehensive prison treatment programming for female offenders may be the Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 428 J. Y. Sacks et al. intervention of choice for meeting the interrelated needs of women in the criminal justice system who have multiple psychiatric diagnoses, accompanied by severe emotional, behavioral and lifestyle disabilities and dysfunction. The prevalence data also point to the need for better mental health screening, assessment, diagnostic and treatment procedures for female offenders, including rapid determination of a need for psychopharmacological and other mental health interventions. Effective treatment cannot be offered if individual needs are not assessed thoroughly. Recent studies and reviews have identified appropriate instruments for screening (Sacks, 2008; Sacks et al., 2007a, 2007b) and assessment (Peters, Bartoi, & Sherman, unpublished document) and have determined those psychopharmacological interventions that are most effective in treating individuals with severe mental disorders (Green, Drake, Brunette, & Noordsy, 2007; Lieberman et al., 2005). Six-month Post-prison Outcomes: Number of Diagnoses Contrary to the hypothesis, the primary analysis (using MANCOVA) did not find a significant relationship between number of DSM-IV Axis I diagnoses and improvement at follow-up; women in all diagnostic groups improved. That is, there was no evidence that female offenders with more diagnoses were less able to benefit from prison substance abuse treatment. A potential factor influencing this outcome is that all women at Denver Women’s Correctional Facility (DWCF) receive, upon admission, a comprehensive standardized assessment for mental health and substance abuse treatment needs, which identifies those women who are to receive follow-up psychiatric assessment, psychopharmacology, and mental health counseling, as well as substance abuse treatment, as indicated. Prison resources are allocated so that all women who are assessed as needing psychiatric assessment and psycho-pharmacological treatment receive such services without delay. In this study, for those offenders with more severe diagnostic profiles, the rapid provision of psychotropic medication to stabilize symptoms may have facilitated responsiveness to the substance abuse treatment programs. Six-month Post-prison Outcomes: E Versus C The study did not find a significant interaction between the number of diagnoses and treatment condition at follow-up, which is reflected in the primary analysis and in the pattern of effect sizes. For all diagnostic groups, the TC, as modified for female offenders, was significantly more effective than the control cognitive behavioral program overall, and on measures of mental health symptoms and HIV sexual risk. Recent studies of women receiving community-based programming found that counseling with an integrated focus on substance abuse, trauma, and mental health issues had promising substance abuse and mental health outcomes (Cocozza et al., 2005; Morrissey et al., 2005). The TC prison treatment that proved effective for the participants in this study was adapted to suit female offenders in several ways; programming was trauma informed and trauma sensitive by virtue of ensuring staff training regarding the functional impacts of historic exposure to trauma/abuse; Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 429 screening/assessment and treatment planning for co-occurring serious mental illness and substance use disorders for all entering inmates was assured; timely access to psychopharmacology and mental health counseling was integrated within the program; and the program incorporated components for dual recovery and to impart the emotional and behavioral coping skills needed to prevent relapse and recidivism. The findings reported here suggest that this TC treatment program, as modified, represents an effective model of treatment for female offenders with co-occurring disorders whose diagnoses and symptom severities vary in complexity. Sensitivity Analysis As an alternative to the number of diagnoses, sensitivity tests were conducted to explore the relationship between individual diagnoses and outcomes at the 6 month follow-up using MANCOVA. The main effects (as well as domain-level effects) for three lifetime diagnoses (major depression, bipolar I/II, and PTSD) were not significant in predicting change from baseline to 6 months post-prison release. A second sensitivity analysis was conducted for current (in the past year) number of diagnoses. Again, the main effect resulting for the number of diagnoses was not significant. A third test of current psychological symptomatology also found no significant relationship between the symptoms reported at intake and those cited at outcome, 6 months after prison release, even when the subject pool included only those with clinically severe symptom levels (GSI > 63). The TC was significantly more effective than the control treatment for all of these models, supporting the evidence of effectiveness of the TC, as modified, for female offenders with multiple diagnoses and diagnostic severity. Limitations This report was structured to investigate profile and outcome differences for female offenders with substance use disorders who had been grouped according to the complexity of their co-occurring Axis I psychiatric disorders, which was defined as multiplicity of Axis I mental diagnoses (lifetime). Data were limited to Axis I mental disorders, and to six modules of the DIS-IV that reflect those diagnoses with greatest prevalence in the system, and did not include either Axis I substance abuse/ dependence (CDOC assessments had identified all participants as having severe substance abuse problems that required treatment), Axis II diagnoses, or Axis I diagnoses of lower prevalence (e.g. psychotic disorders). While acknowledging that severity is more complicated than can be described by classification according to the number of positive diagnoses, the findings do show a consistent and linear pattern of dysfunction associated with the number of Axis I mental disorders. Future research that focuses on the full array of Axis I and Axis II diagnoses could add greatly to our understanding of the multiple patterns of diagnostic complexity in the population of female offenders. Research that is inclusive of the full array of Axis I and Axis II mental disorders is needed to explore and clarify the needs of offenders with multiple patterns of diagnostic complexity, and the impact of particular clusters of diagnoses on treatment outcomes. Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl 430 J. Y. Sacks et al. Although adequate for a preliminary analysis, the sample size was limited to a subgroup of participants randomly selected to receive the DIS-IV interview. Analyses investigating selection bias revealed few significant differences between participants who completed the DIS-IV and those who did not, indicating that selection bias was minimal. The analyses presented here did not evaluate other threats to validity, including treatment dose, time at risk, reincarceration outcomes, or the effects of possible moderators (e.g. homelessness and recent trauma exposure). Whenever possible, future research should include tests of moderators, sensitivity, and validity to extend the main findings. This is particularly relevant in criminal justice settings, where stakeholders often raise criticisms of findings from offender treatment research (see, e.g., Farabee, 2005). Summary and Conclusions Other studies of the investigative team have demonstrated the effectiveness of a modified TC program for male offenders with co-occurring disorders in terms of crime (Sacks et al., 2004a) and substance use outcomes (Sullivan et al., 2007). The study reported here extends the utility of the modified TC model to include female offenders across a range of Axis I diagnostic complexity. The outcomes currently reported are also consistent with the findings from a recent literature review by Drake, O’Neal, and Wallach (2008), which concluded that residential programming (including TC treatment) was one of only three approaches (in addition to group counseling and contingency management) that were effective in improving substance use outcomes for severely mentally ill clients with co-occurring substance use disorders. Given today’s cost-consciousness and limited resources, it is imperative to continue to identify those clients with the greatest needs who are most likely to benefit from comprehensive treatment approaches of longer duration. The prison is one setting in which these approaches might be particularly viable because the incremental cost of such treatments is relatively modest (French, McCollister, Sacks, McKendrick, & De Leon, 2002; French, Sacks, De Leon, Staines, & McKendrick, 1999; McCollister et al., 2003). Correctional systems need to be cognizant of the fact that female offenders with severe and chronic substance use problems are highly likely to have a co-occurring mental disorder, and a significant percentage of the women are likely to have multiple Axis I serious psychiatric disorders. Preliminary data found no relationship between diagnostic complexity (i.e. the number of Axis I diagnoses) and 6 month post-prison treatment outcomes across five domains (i.e. mental health, trauma exposure, substance use, HIV needle risk behaviors, and HIV sexual risk); however, further research is needed to examine the full array of Axis I and Axis II disorders in relation to treatment outcome for female offenders. The experimental TC (as modified), which provides comprehensive, integrated services for female offenders with cooccurring disorders, was significantly more effective than the control cognitive behavioral program across all mental disorder severity groups overall, and on measures of mental health symptoms and HIV sexual risk. These preliminary findings suggest that this TC program, as modified, is an effective model for women in the correctional system with complex diagnoses and symptom severities. Copyright # 2008 John Wiley & Sons, Ltd. Behav. Sci. Law 26: 413–434 (2008) DOI: 10.1002/bsl Treatment outcomes for female offenders: relationship to number of Axis I diagnoses 431 ACKNOWLEDGEMENTS The study was funded under a grant, #5DA014370-[01-05], from the U.S. Department of Health and Human Services (DHHS), National Institutes of Health (NIH) and the National Institute on Drug Abuse (NIDA). 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