2004
Azetidine derivatives
R 0045
β-Lactam Synthesis by Ugi Reaction of β-Keto Acids in Aqueous Solution. —
The Ugi reaction of β-keto acids such as (I), primary amines and isonitriles is efficiently
45- 120 accelerated
by aqueous glucose solution as the reaction medium. — (PIRRUNG*, M.
C.; SARMA, K. D.; Synlett 2004, 8, Special Issue, 1425-1427; Dep. Chem., Levine
Sci. Res. Cent., Duke Univ., Durham, NC 27708, USA; Eng.) — Mais