2005
Multi-membered O,N,S-heterocycles
Multi-membered O,N,S-heterocycles
R 0692
2-Substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one
a Structurally New NK1 Antagonist. — Title compound (V) shows strong NK1 an28- 179 as
tagonist activity. — (SETO*, S.; TANIOKA, A.; IKEDA, M.; IZAWA, S.; Bioorg.
Med. Chem. Lett. 15 (2005) 5, 1485-1488; Discovery Res. Lab., Kyorin Pharm. Co.,
Ltd., Shimotsuga, Tochigi 329-01, Japan; Eng.) — C. Oppel