2005
Purine derivatives
R 0540
Optimization of Purine Based PDE1/PDE5 Inhibitors to a Potent and Selective
Inhibitor for the Treatment of Male ED. — Title compounds such as (I) and
35- 184 PDE5
(II) are synthesized and tested for their PDE5 potency. — (BOYLE*, C. D.; et al.;
Bioorg. Med. Chem. Lett. 15 (2005) 9, 2365-2369; Schering-Plough Res. Inst.,
Kenilworth, NJ 07033, USA; Eng.) — R. Langenstrassen